Road Trip On The Great River Road (Along The Mississippi River)

Every road trip has its own charm, but there’s something magical about cruising along the Mississippi River. The Great River Road offers an unparalleled journey spanning ten states, from the frigid waters of Minnesota’s Lake Itasca to the Gulf Coast’s balmy vistas in Louisiana. With its rich history, diverse ecosystems, and vibrant culture-infused cities, the Great River Road offers an unforgettable adventure. So pack your bags, load up your favorite road trip playlist, and let’s embark on this epic trip. 

Whether you relish the thrill of zipping through the route’s central artery, bask in the radiant beauty of scenic paths, want an unusual, fun-filled drive, or are planning this excursion with kids or pets, we have meticulously crafted five unique route options to cater to your individual needs and make your journey memorable. Each route is packed with must-see attractions, perfect coffee stops, and plenty of photo opportunities. 

Engage with cities where the pulsating beat of jazz wafts through the air, rural landscapes that unfurl like beautiful pieces of patchwork, and panoramic views that inspire awe and wonder. The Great River Road is an invitation to explore the heartland of America, to understand its roots, and to fall in love with its undeniable charm. It’s more than just a road: it’s a living, breathing testament to the stories, triumphs, and dreams that have shaped this great nation. 

But, remember, no two trips on the Great River Road are the same. The road adapts and reveals itself differently to each traveler. It’s a road of discovery, of unexpected delights and heartfelt connections. So lace up your explorer boots, let the wanderlust take over, and write your own story on the Great River Road.

The Fast Lane: Zooming Along the Great River Road

For travelers short on time or just keen on covering the vast expanse of the Great River Road swiftly, this route is precisely carved out. It allows you to ride the primary arteries of the highway, skipping some of the more time-consuming detours but still delivering a taste of the majestic Mississippi’s charm. Be ready to engage in a whirlwind experience that lets you journey through ten states swiftly, all while taking delight in glimpses of the magnificent river and its surroundings. 

Route Directions and Driving Time 

1. Start in Itasca State Park, Minnesota; head south on Minnesota State Highway 200.
2. Switch to US Highway 10 in Lake Park.
3. Continue onto I-94 E, I-694 E and I-494 S to Hastings.
4. Fall in line with US-61 S, the main artery of the Great River Road, which leads you through Winona, La Crosse, Prairie du Chien, and Dubuque.
5. Stick to US-61 S till St. Louis taking you through towns of Hannibal, Bowling Green, and Troy.
6. On reaching Memphis, shift onto I-55.
7. Continue this trajectory till New Orleans, your final destination.
8. Encompassing approximately 2000 miles, this efficient route can be covered in just 30+ hours of driving time.

Must-See Attractions 

Zooming along the Great River Road doesn’t mean you will miss out on all the charming attractions. Here are a few must-see spots that can be integrated into your swift itinerary: 

• Itasca State Park: Starting your journey at Lake Itasca lets you witness the birthplace of the Mississippi River. The park offers incredible natural beauty and the ‘headwaters’ site, and can make for a great place to take a quick photo and stretch your legs.
• Twin Cities Minneapolis and Saint Paul: The cityscape breaks the monotony of the drive. The iconic ‘Mighty Mississippi’ board marking the entry into the cities is a sight not to be missed.
• Gateway Arch, St. Louis: This emblem of the city’s nickname ‘Gateway to the West’ requires a short stop. Lit up at night, the arch over the Mississippi makes for a splendid sight.
• Graceland, Memphis: Even if you don’t have time for a full tour, a drive by Elvis Presley’s estate is a must. The musical history in the air is palpable.
• French Quarter, New Orleans: A quick stroll around the French Quarter at the end of your drive will serve as a beautiful close to your tour. Don’t miss the chance to indulge in a quick beignet or spicy jambalaya!

Rest-Stops & Coffee Shops 

The fast lane requires frequent refueling, both for you and your vehicle. Here are some charming stops to rest and refresh: 

• Sparrow Cafe, Minneapolis: A perfect spot for a swift pick-me-up. Their famed ‘Birdie’ espresso is a hit among travelers.
• The Mud House, St. Louis: It’s a great place to grab a quick bite. Try their sandwiches and strong coffee.
• Tamp & Tap, Memphis: Known for their excellent brews and a quick yet delicious food menu.
• Cafe du Monde, New Orleans: A visit to New Orleans would be incomplete without a swift stop at Cafe du Monde for a beignet and cafe au lait.

Unusual and Fun: An Adventure Off the Beaten Path

Why take the conventional route when you can jump off the beaten path and indulge in some truly unforgettable scenes and experiences? Gear up for an offbeat adventure that pulses with the vibrant spirit of the mighty Mississippi, showcasing its more unusual and fun attractions. 

Route Highlights 

Prepare to be blown away by the spectacular array of wildlife sanctuaries, unexplored towns and unusual attractions dotting this route. Stretch your legs with a detour to hidden scenic vistas, dip into eccentric localities, meet some quirky characters, and soak up a unique American culture. 

Route Directions & Driving Time 

• Begin your journey in Itasca State Park, Minnesota, the official source of the Mississippi River.
• Travel on Highway 61
• Turn east onto Highway 10 towards the mysterious Kensington Runestone Park.
• Get back on Highway 61 south to Dubuque, where you can enjoy the dubious honor of visiting a haunted brewery.
• Follow the Great River Road south to Hannibal, exploring the intriguing world of Mark Twain.
• Head south on Route 79, a lesser-known route with unique attractions all its own.
• Finally, end your journey in New Orleans, Louisiana, a city that requires no introduction.

This unusual route will take approximately 3-4 days, depending on how much time you spend exploring each stop. 

Must-See Attractions 

• Kensington Runestone Park: A mysterious stone here has sparked huge controversy about the Vikings in America.
• Dubuque Star Brewery: Taste some local brews in a brewery that’s rumored to be haunted.
• Mark Twain’s Boyhood Home: Hannibal was the inspiration for the adventures of Tom Sawyer and Huckleberry Finn; visiting Twain’s boyhood home brings these stories to life.
• Maid Rite: A well-known “loose meat” sandwich shop that has been serving customers for almost 100 years.
• The City Museum in St. Louis: An unusual museum offering fun, interactive exhibits made from reclaimed architectural materials.
• Shack Up Inn: An offbeat overnight spot in Clarksdale, Mississippi, offering lodging in restored plantation shacks.
• French Quarter: End your journey dipping in NOLA’s jazz music, unique architecture, mystical folklore, and deliciously varied cuisine.

Rest-Stops & Coffee Shops 

Between the spectacles and sights, stop by some of the route’s charming cafes and eateries. In Minnesota, visit the Bohemian Bean coffee shop for a unique coffee experience. Mid-route, in Hannibal, the Mark Twain Dinette offers classic American diner food. Towards the end of your journey, stop at Café du Monde in New Orleans for their world-renowned beignets and cafe au lait.

Family Fun on the Great River Road: A Route for Kids

If you’re planning to share the grandeur and beauty of the Great River Road with your youngsters, you’ll want to take the family-friendly route that brims with entertainment, education, and effortless travel. This journey focuses not just on the scenery, but also on places that will captivate kids and keep their spirits high between lurid road games and napping time. 

Route Highlights 

• The home of a real-life castle at the Quincy Museum.
• The world below the surface at the National Mississippi River Museum & Aquarium.
• 500 different species at the Memphis Zoo.
• Children’s Museum of La Crosse for hands-on learning and fun.

Route Directions & Drive Time 

1. Start from Minneapolis, and take the I-94W and US-10W to Saint Cloud.
2. Follow US-10W and continue on MN-371N to Brainerd.
3. Take MN-210E and US-169S for a stop in St. Paul.
4. Follow US-61S down to Red Wing and then towards La Crosse.
5. Continue on US-61S to Dubuque, IA and then to Davenport, making sure to stop by the National Mississippi River Museum & Aquarium.
6. Stay on US-61S to Memphis, TN for a fun zoo visit. Continue on this route all the way down to New Orleans, LA.

Approximate total driving time for this trip is 17 hours over a distance of about 1200 miles. Remember, the experience is best enjoyed when spread over several days, at a leisurely pace. 

Must-See Attractions 

1. Quincy Museum: This delightful museum in Quincy, Illinois, has exhibits on natural history, Victoriana, and a children’s interactive gallery set in a stunning historic mansion.
2. National Mississippi River Museum & Aquarium: Located in Dubuque, Iowa, it’s a one-stop-shop for educational and interactive exhibits on the ecology and history of America’s greatest river.
3. City Museum, St. Louis: In St. Louis, older kids will marvel at the 10-story slide and the labyrinth of caves in this unique playground.
4. Memphis Zoo: With pandas, sea lions, penguins, and more, the Memphis Zoo is a joy for all ages.
5. New Orleans’ Audubon Aquarium of the Americas: Finally, in New Orleans, the Audubon Aquarium of the Americas is among the nation’s finest, with an impressive display of marine life.

Rest-Stops & Coffee Shops 

Proper rest-stops and meal breaks will make this journey all the more enjoyable. Installments like Betty’s Cafe in Quincy, Capanna Coffee in Iowa City, or Stella’s Café in De Witt are fantastic options where adults can obtain their caffeine fix, and the kids can enjoy a delightful snack. In the deep south, try the casual and child-friendly eateries in Memphis like Brother Juniper’s or Memphis Pizza Café.

Kid-Friendly Delights: Must-See Attractions for Children

On your journey, don’t miss out on the excellent kid-friendly attractions that hold the charm of being fun-filled, educational, and interactive at the same time. These spots will keep your young explorers engaged and entertained throughout the trip, while you get to capture their blissful smiles amid enchanting landscapes. 

Route Highlights 

• The merging of play and learning at the Children’s Science Museum in Davenport, IA.
• A walk back in time at the Mark Twain Boyhood Home & Museum in Hannibal, MO.
• Train rides that whisk you to the past on the Twin City Model Railroad Museum in St. Paul, MN.
• Animated adventures await at Tom Sawyer’s Playland in St. Louis, MO.
• Wildlife encounters at the National Eagle Center in Wabasha, MN.

Route Directions & Driving Time 

• Start at Davenport, IA, heading to the Children’s Science Museum (15 minutes).
• Drive southward towards Hannibal, MO (About 3 hours).
• Get on US-61 N to St. Paul, MN (Approximately 6 hours).
• Now, take I-55 S back to St. Louis, MO (Around 5 hours).
• Finally, head back north towards Wabasha, MN (4 hours).

Must-See Attractions 

The Children’s Science Museum is a haven of educational exhibits that allow children to learn through interaction and inquiry. The Mark Twain Boyhood Home & Museum sparks their imagination by leading them into the world of Huckleberry Finn. The Twin City Model Railroad Museum offering a glimpse into the locomotive history is a delight for train-loving kiddos. Adding thrill to the journey, the Tom Sawyer’s Playland lets the children step into the shoes of the classic characters. Closing the trip with a feathered surprise, the National Eagle Center mesmerizes them with a close encounter with the majestic birds. 

Rest-Stops & Coffee Shops 

Take a wholesome pause at the Funky Java Coffee Shop in Davenport, enjoy a quick bite at Mark Twain Dinette in Hannibal, sample the famed sandwiches at Mickey’s Diner in St. Paul, make a flavorful stop at Blues City Deli in St. Louis, and unwind with a hot cup at the Turning Waters Coffee House in Wabasha. Each stop is unique, blending the joy of a refreshing break with the essence of local flavor.

Bringing Fido: Exploring the Great River Road with Your Pooch

Bringing your canine companion along on your Great River Road trip is not only doable but also downright enjoyable. This route caters to both human and canine needs, offering a range of dog-friendly lookouts and leisure activities. Appreciate the beautiful Mississippi River, while allowing your dog to enjoy new sights, sounds, and sniffs. You’ll find specifically catered parks, dog-friendly accommodations, and eateries that welcome you and your pooch. 

Route Directions & Driving Time 

1. Start your journey in Itasca State Park, Minnesota, famed for its lake where the Mighty Mississippi starts. It welcomes dogs in most parts.
2. Drive south towards La Crosse, Wisconsin. Take time out along the river to stop in dog-friendly parks.
3. Proceed to Alton, Illinois, making a pit stop at the TreeHouse Wildlife Center.
4. Proceed towards Saint Louis, Missouri. The Gateway Arch National Park is a good spot to stretch.
5. Drive down to Memphis, Tennessee. Visit one of the dog parks or walk in downtown.
6. Continue south to Vicksburg, Mississippi. Stop by its Military Park for a natural stroll.
7. Conclude your adventure in Venice, Louisiana, the end of the Great River Road. Bring your pooch to a pet-friendly beach.

Estimated total driving time is 18 hours, excluding breaks. 

Must-See Attractions 

• Itasca State Park, Minnesota: A beautiful park where dogs on leash can explore miles of trails and enjoy picnic areas.
• Lake Onalaska, near La Crosse, Wisconsin: Discover its doggie beach where your furry friend can cool down in the water.
• TreeHouse Wildlife Center, Illinois: An animal rehabilitation center that you can explore with your furry friend on leash.
• Gateway Arch National Park, Missouri: Enjoy this downtown park, where leashed dogs are allowed on the trails and open areas.
• The Shelby Farms Park, Memphis, Tennessee: Offers a 100-acre off-leash area known as “The Outback,” perfect for your dog to stretch their legs and interact with other dogs.
• Vicksburg National Military Park, Mississippi: Enjoy a quiet, scenic stroll and view the monuments, with a leash-wearing dog in tow.
• Fort Jackson Beach, Louisiana: A pet-friendly beach where your dog can enjoy the sea breeze and shoreline.

Rest-Stops & Coffee Shops 

When you need to rest, check out dog-friendly establishments like JavaVino in La Crosse, Wisconsin, and Mokabi Coffee in Saint Louis, Missouri. Both offer outdoor seating where your dog is welcome. In addition, numerous rest areas along the Great River Road provide spaces for your dog to relieve themselves and stretch their legs.

Nature’s Wonders: Scenic Stops for Birdwatching and Hiking

If you are an outdoor enthusiast and want your road trip to be imbued with the splendor of the Mississippi River’s natural scenery, then this scenic route with stops for birdwatching and hiking is tailor-made for you. 

Route Intro & Highlights 

The Nature’s Wonders expedition will lead you through some of the most verdant, rich ecosystems along the Great River Road. Here, you’ll see a myriad of bird species in their natural habitats and revitalize your senses with verdant trails through picturesque landscapes. Some key highlights include the Upper Mississippi River Wildlife and Fish Refuge, the Audubon Center at Riverlands, and the Arkansas State Parks. 

Route Directions & Driving Time 

1. Start in Minnesota’s Lake Itasca, the source of the Mississippi River, and head southward.
2. Continue to La Crosse, Wisconsin, and visit the Upper Mississippi River Wildlife and Fish Refuge.
3. Proceed to Dubuque, Iowa, and spend some time at the Mines of Spain Recreation Area.
4. Drive to Quad Cities and take the scenic route in Rock Island.
5. Follow the river to Hannibal, Missouri, the hometown of Mark Twain.
6. Head to Alton, Illinois, and visit the Audubon Center at Riverlands.
7. Travel onwards to Cairo, and then into the state of Arkansas.
8. Finally, end your journey at the Arkansas Post National Memorial. The total driving time is approximately 12-14 hours, spread across several days to fully enjoy the stops.

Must-See Attractions 

• Upper Mississippi River Wildlife and Fish Refuge: This is the largest river refuge in the United States, housing an impressive array of waterfowl, migratory birds, and fish species.
• Mines of Spain Recreation Area: A natural and historic paradise, full of hiking trails, wildlife observation areas, and historical sites.
• Audubon Center at Riverlands: Home to more than 200 bird species throughout the year, it’s a haven for bird lovers.
• Arkansas State Parks: These parks offer a wealth of nature-based activities, such as birdwatching, hiking, and camping.

Rest-Stops & Coffee Shops 

• Itasca State Park: Perfect for a rest, complete with a diner and coffee shop.
• The Freight House Restaurant: Located in La Crosse, Wisconsin, ideal for lunch.
• Grounds for Celebration: In Quad Cities, grab your caffeine fix here.
• Arkansas Post Museum State Park: End your journey with a rest in the visitor center, with a good cup of coffee for refreshment.

A Cultural Crusade: Art, Music, and Festivals on the Great River Road

Following the Great River Road offers not only breath-taking views and strikingly diverse landscapes, but also a treasure trove of cultural experiences. From vibrant art galleries to lively music festivals and slices of history, this route escorts you to an enriching journey through America’s rich cultural heritage. 

Route Directions & Driving Time 

1. Start your journey in Itasca State Park, Minnesota and follow the Great River Road south.
2. Pass through the bustling cities of St. Paul and Minneapolis.
3. Continue into Wisconsin, skirting the river’s edge through Prairie du Chien and La Crosse.
4. Enter Iowa, and make sure to stop at Dubuque.
5. Traverse Illinois, stopping in cities like Quincy, Hannibal and St. Louis.
6. Cross into the subtropical climate of Missouri, Arkansas, Mississippi and finally Louisiana, ending in the vibrant city of New Orleans.

Approximate driving time: 36-40 hours. 

Must-See Attractions 

• The Walker Art Center and Sculpture Garden, Minneapolis: Renowned for its innovative programming, this contemporary art center hosts compelling exhibitions and performances. Don’t miss the iconic Spoonbridge and Cherry sculpture!
• The National Mississippi River Museum and Aquarium, Dubuque: Offering up interactive displays about the river’s history, wildlife, and conservation efforts, it’s educational and fun for the whole family.
• The Gateway Arch, St. Louis: The tallest man-made monument in the US provides an outstanding view of the Mississippi.
• BB King Museum and Delta Interpretive Center, Indianola: Learn about the electrifying blues legend and his impact on music history.
• New Orleans Jazz & Heritage Festival: Celebrating the rich musical and cultural history of Louisiana, this iconic festival features some of the hottest names in jazz, gospel, blues and rock.

Rest-Stops & Coffee Shops 

Fuel your cultural crusade with these great stops: 

• A Baker’s Wife’s Pastry Shop, Minneapolis: A small bakery exuding old-school charm and serving up arguably the best doughnuts in the Twin Cities.
• Monk’s Café, Dubuque: A classic coffee shop and ideal for a quick bite amid your cultural exploration.
• Sump Coffee, St. Louis: Known for its artistic approach to coffee making.
• Beale Street Historic District, Memphis: Brimming with signature blues clubs and restaurants, the street that launched the careers of many blues artists.
• Café Du Monde, New Orleans: Famous for the beignets and café au lait, a quintessential stop in the Big Easy.

Immerse in Local Culture: Must-Visit Museums and Galleries

Immerse yourself in the rich tapestry of American history and culture with this route that compiles must-visit museums and galleries along the Great River Road. Travel from Minnesota to Louisiana, exploring the diverse communities that have shaped the country’s identity. This journey offers an exceptional opportunity to understand the region’s past while enjoying local arts scenes that range from folk traditions to avant-garde exhibits. 

Route Directions & Driving Time 

1. Start in Minneapolis, Minnesota, with a visit to the Minneapolis Institute of Art.
2. Drive south on Interstate 35, then onto US-52 S, towards Rochester, where you can explore the Historic Mayowood Mansion.
3. Continue your drive south on US-51 until reaching Madison, Wisconsin, and visit the Madison Museum of Contemporary Art.
4. Head south on US-61, making your way to Davenport, Iowa, home to Figge Art Museum.
5. Stay on US-61 and drive towards Hannibal, Missouri, which houses the Mark Twain Boyhood Home & Museum.
6. Your final destination is New Orleans, Louisiana. A visit to The National WWII Museum in New Orleans is a must.

The total driving time for this route is around 17 hours, covered over several days to fully appreciate the extensive array of cultural offerings. 

Must-See Attractions 

• Minneapolis Institute of Art, Minneapolis: One of the most significant art museums in the country, featuring works from six continents over 5,000 years.
• Historic Mayowood Mansion, Rochester: A 38-room mansion showing how Mayo Clinic founders and their families lived.
• Madison Museum of Contemporary Art, Madison: Offering free admission, this museum houses a significant collection of modern and contemporary visual art.
• Figge Art Museum, Davenport: Displays an impressive collection of American art, including works by Grant Wood and Andy Warhol.
• Mark Twain Boyhood Home & Museum, Hannibal: The childhood home of Mark Twain is a literary tour-de-force worth noting.
• The National WWII Museum, New Orleans: America’s official WWII museum emphasizes the American experience during WWII.

Rest-Stops & Coffee Shops 

Throughout your exploration, take a break to enjoy the fresh coffee aromas and delicious local cuisine at unique rest stops, cafes and restaurants. Some notable mentions include: 

• Spyhouse Coffee, Minneapolis: Renowned for its coffee, it’s a perfect place for a morning caffeine fix.
• Fiddlehead Coffee Co., Rochester: A city favorite, known for their locally-sourced menu and friendly, casual atmosphere.
• Graze, Madison: An ideal rest-stop for lovingly prepared, locally sourced food.
• Redband Coffee Company, Davenport: A funky coffee shop offering robust coffee and pastries.
• Java Jive, Hannibal: An amazing little coffee shop in the heart of Hannibal with an eclectic atmosphere and delicious drinks.
• Café Du Monde, New Orleans: Renowned for its café au lait and freshly-made beignets.

Final Thoughts

The Great River Road promises an unforgettable journey, filled with breathtaking scenery, captivating history, diverse wildlife, and charming small-town cultures. Each route from the fastest to the one ideal for kids or pets offers unique landscapes and experiences. You could go on this journey over and over, taking a different route each time, and still find new adventures and spectacles. Remember, irrespective of the route you choose, the magic lies in the journey as much as the destination. 

As you navigate this historic and gorgeous road, you’ll find that every mile marker holds a moment of awe or a point of interest. And not just big, headline-worthy points of interest—like towering bluffs or sprawling wildlife refuges—but smaller, quieter moments of wonder as well. An opportunity to pause, take a deep breath, and admire the radiant sunset over the river. A chance encounter with an eagle soaring above or a deer grazing peacefully. A friendly chat with a local artist or a storeowner who feels like a character from an old, heartwarming novel. That’s the sort of memory-making magic that awaits you on the Great River Road. 

No matter what you’re in the mood for – scenic drives, historical sites, outdoor adventures, a family trip, or a pet-friendly journey – the Great River Road is sure to fascinate and thrill you. Plan your road trip, pack your suitcase, rev up the engine, and let the Mississippi guide you on an exciting exploration. 

Finally, while you embrace the call of the open road, remember the importance of being respectful explorers. Let’s appreciate and respect the local communities, cultures, and natural surroundings we’re privileged to visit. The Great River Road has been here hundreds of years. It’s our responsibility to ensure it remains a source of joy and amazement for hundreds more. 

So, what are you waiting for? Your epic adventure on the Great River Road begins now. Embark on the journey of a lifetime and make unforgettable memories along these routes. Safe travels!